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KMID : 0861020170320060063
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Korea Journal of Herbology
2017 Volume.32 No. 6 p.63 ~ p.69
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Effects of Yeonsan-Ogye Egg on MIA-induced Osteoarthritis Rat
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Joo In-Hwan
Kim Dong-Hee
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Abstract
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Objectives : The purpose of this study is to investigate the preventive and therapeutic efficacy of osteoarthritis using a Yeonsan-Ogye egg. so, we researched at effects of Yeonsan-Ogye egg extract on MIA-induced Osteoarthritis animal models.
Methods : Yeonsan-Ogye egg extract was administered 500 ㎎/㎏/day, 1000 ㎎/㎏/day and 2000 ㎎/㎏/day to SD-Rat for 2 weeks. After that, osteoarthritis was induced with 60 ㎎/㎖ of monosodium iodoacetate (MIA) and futher administration was continued for 4 weeks. 3D imaging of cartilage patella were obtained using a Micro-CT system and the pathology change of knee was observed by H&E and safranin-O staining. The weight bearing ratio was measured by incapacitance test meter. MMP-2, MMP-9, COMP, CTXⅡ, calcitonin and glycosaminoglycan level in serum were measured using a ELISA.
Results : Micro-CT and Histopathological analysis showed the volume of the patella cartilage and the proteoglycan contents were increased in all groups. also weight bearing ratio was decreased in all groups compared with control group. Calcitonin production was increased in and 2000 ㎎/㎏/day group and glycosaminoglycan production was increased in all groups. In addition, MMP-2, MMP-9, COMP and CTX Ⅱ production were decreased in 1000 and 2000 ㎎/㎏/day groups respectively in comparison with control.
Conclusions : The results for Yeonsan-Ogye egg showed prevention and treatment efficacy against arthritis at serum and the cartilage. These results may be used a remedy for new korea medicine to ease the symptoms mentioned above. also, suggest that Yeonsan-Ogye egg can be used preventive and therapeutic material for osteoarthritis.
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KEYWORD
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bone metabolism, korean medicine remedy, osteoarthritis, Yeonsan-Ogye, Yeonsan-Ogye egg
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